IK (gene)

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Aliases IK, CSA2, RED, IK cytokine, down-regulator of HLA II, RER
External IDs MGI: 1345142 HomoloGene: 36193 GeneCards: IK
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for IK
Genomic location for IK
Band 5q31.3 Start 140,647,058 bp[1]
End 140,662,479 bp[1]
RNA expression pattern
PBB GE IK 200066 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 140.65 – 140.66 Mb Chr 5: 36.74 – 36.76 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Protein Red is a protein that in humans is encoded by the IK gene.[5][6]

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113141 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024474 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization". Oncogene. 9 (12): 3449–56. PMID 7970704. 
  6. ^ a b "Entrez Gene: IK IK cytokine, down-regulator of HLA II". 

Further reading[edit]

  • Cao LX, Le Bousse-Kerdiles MC, Clay D, et al. (1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation.". Blood. 89 (10): 3615–23. PMID 9160666. 
  • Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat.". Gene. 230 (2): 145–54. PMID 10216252. doi:10.1016/S0378-1119(99)00066-9. 
  • Willers J, Häffner A, Zepter K, et al. (2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation.". J. Invest. Dermatol. 116 (6): 874–9. PMID 11407974. doi:10.1046/j.1523-1747.2001.01339.x.