IL12A

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IL12A
Protein IL12A PDB 1f45.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL12A, CLMF, IL-12A, NFSK, NKSF1, P35, interleukin 12A
External IDs MGI: 96539 HomoloGene: 681 GeneCards: IL12A
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000882

NM_001159424
NM_008351

RefSeq (protein)

NP_000873

NP_001152896.1
NP_032377.1
NP_001152896
NP_032377

Location (UCSC) Chr 3: 159.99 – 160 Mb Chr 3: 68.69 – 68.7 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene.[3]

Function[edit]

This gene encodes a subunit of the cytokine Interleukin 12 (IL-12) that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-dependent induction of interferon gamma (INF-γ), and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM (May 1991). "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells". J Immunol. 146 (9): 3074–81. PMID 1673147. 
  4. ^ "Entrez Gene: IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)". 

Further reading[edit]