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Interleukin 17 receptor A
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL17RA ; CANDF5; CD217; CDw217; IL-17RA; IL17R; hIL-17R
External IDs OMIM605461 MGI107399 HomoloGene7378 IUPHAR: 1738 GeneCards: IL17RA Gene
RNA expression pattern
PBB GE IL17RA 205707 at tn.png
More reference expression data
Species Human Mouse
Entrez 23765 16172
Ensembl ENSG00000177663 ENSMUSG00000002897
UniProt Q96F46 Q60943
RefSeq (mRNA) NM_001289905 NM_008359
RefSeq (protein) NP_001276834 NP_032385
Location (UCSC) Chr 22:
17.08 – 17.12 Mb
Chr 6:
120.46 – 120.48 Mb
PubMed search [1] [2]

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.[1]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.