IL17RA

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IL17RA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R, interleukin 17 receptor A, IMD51
External IDsMGI: 107399 HomoloGene: 7378 GeneCards: IL17RA
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for IL17RA
Genomic location for IL17RA
Band22q11.1Start17,084,954 bp[1]
End17,115,694 bp[1]
RNA expression pattern
PBB GE IL17RA 205707 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014339
NM_001289905

NM_008359

RefSeq (protein)

NP_001276834
NP_055154

NP_032385

Location (UCSC)Chr 22: 17.08 – 17.12 MbChr 6: 120.46 – 120.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.[5]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.[5]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.