IL18BP

From Wikipedia, the free encyclopedia
Jump to: navigation, search
IL18BP
Identifiers
Aliases IL18BP, IL18BPa, interleukin 18 binding protein
External IDs MGI: 1333800 HomoloGene: 7781 GeneCards: IL18BP
RNA expression pattern
PBB GE IL18BP 219323 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010531

RefSeq (protein)

NP_034661.1
NP_034661

Location (UCSC) Chr 11: 72 – 72.01 Mb Chr 7: 102.01 – 102.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.[3][4]

The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–36. doi:10.1016/S1074-7613(00)80013-8. PMID 10023777. 
  4. ^ a b "Entrez Gene: IL18BP interleukin 18 binding protein". 

Further reading[edit]

External links[edit]