IL18BP

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IL18BP
Identifiers
AliasesIL18BP, IL18BPa, interleukin 18 binding protein
External IDsMGI: 1333800 HomoloGene: 7781 GeneCards: IL18BP
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for IL18BP
Genomic location for IL18BP
Band11q13.4Start71,998,541 bp[1]
End72,005,715 bp[1]
RNA expression pattern
PBB GE IL18BP 219323 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010531
NM_001363982

RefSeq (protein)

NP_034661
NP_001350911

Location (UCSC)Chr 11: 72 – 72.01 MbChr 7: 102.01 – 102.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.[5][6]

The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137496 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070427 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–36. doi:10.1016/S1074-7613(00)80013-8. PMID 10023777. 
  6. ^ a b "Entrez Gene: IL18BP interleukin 18 binding protein". 

Further reading[edit]

External links[edit]