Interleukin 36 receptor antagonist

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IL36RN
Protein IL1F5 PDB 1md6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL36RN, FIL1, FIL1(DELTA), FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, IL-36Ra, PSORS14, interleukin 36 receptor antagonist
External IDs MGI: 1859325 HomoloGene: 10453 GeneCards: 26525
RNA expression pattern
PBB GE IL1F5 222223 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173170
NM_012275

NM_001146087
NM_001146088
NM_019451

RefSeq (protein)

NP_036407.1
NP_775262.1

NP_001139559.1
NP_001139560.1
NP_062324.2

Location (UCSC) Chr 2: 113.06 – 113.07 Mb Chr 2: 24.28 – 24.28 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 36 receptor antagonist is a protein that in humans is encoded by the IL36RN gene. It was previously named Interleukin-1 family member 5 (IL1F5).[1][2][3][4]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.[4]

References[edit]

  1. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660. 
  2. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  3. ^ Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, Kastelein RA, Kumar S, Lin H, Mulero JJ, Pan J, Pan Y, Smith DE, Young PR (Sep 2001). "A new nomenclature for IL-1-family genes". Trends Immunol 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262. 
  4. ^ a b "Entrez Gene: IL36RN interleukin 36 receptor antagonist". 

Further reading[edit]