Interleukin 37

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Interleukin 37
Symbols IL37 ; FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-37; IL1F7; IL1H4; IL1RP1
External IDs OMIM605510 HomoloGene105713 GeneCards: IL37 Gene
RNA expression pattern
PBB GE IL1F7 221470 s at tn.png
More reference expression data
Species Human Mouse
Entrez 27178 n/a
Ensembl ENSG00000125571 n/a
UniProt Q9NZH6 n/a
RefSeq (mRNA) NM_014439 n/a
RefSeq (protein) NP_055254 n/a
Location (UCSC) Chr 2:
112.91 – 112.92 Mb
PubMed search [1] n/a

Interleukin-1 family member 7 is a protein that in humans is encoded by the IL1F7 gene.[1][2][3][4]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.[4]


  1. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660. 
  2. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  3. ^ Gao W, Kumar S, Lotze MT, Hanning C, Robbins PD, Gambotto A (Dec 2002). "Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity". J Immunol 170 (1): 107–13. doi:10.4049/jimmunol.170.1.107. PMID 12496389. 
  4. ^ a b "Entrez Gene: IL1F7 interleukin 1 family, member 7 (zeta)". 

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