Interleukin 37

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IL37
Identifiers
Aliases IL37, FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1, interleukin 37
External IDs HomoloGene: 105713 GeneCards: IL37
RNA expression pattern
PBB GE IL1F7 221470 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014439
NM_173202
NM_173203
NM_173204
NM_173205

n/a

RefSeq (protein)

NP_055254
NP_775294
NP_775295
NP_775296
NP_775297

n/a

Location (UCSC) Chr 2: 112.91 – 112.92 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Interleukin-1 family member 7 is a protein that in humans is encoded by the IL1F7 gene.[2][3][4][5]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660. 
  3. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  4. ^ Gao W, Kumar S, Lotze MT, Hanning C, Robbins PD, Gambotto A (Dec 2002). "Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity". J Immunol. 170 (1): 107–13. doi:10.4049/jimmunol.170.1.107. PMID 12496389. 
  5. ^ a b "Entrez Gene: IL37 interleukin 37". 

Further reading[edit]