IL36B

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IL36B
Identifiers
Aliases IL36B, FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, interleukin 36, beta
External IDs MGI: 1916927 HomoloGene: 18278 GeneCards: IL36B
RNA expression pattern
PBB GE IL1F8 gnf1h00165 at fs.png

PBB GE IL1F8 gnf1h02208 at fs.png

PBB GE IL1F8 gnf1h02207 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014438
NM_173178

NM_027163

RefSeq (protein)

NP_055253
NP_775270

NP_081439.1
NP_081439

Location (UCSC) Chr 2: 113.02 – 113.05 Mb Chr 2: 24.15 – 24.16 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.[3][4][5][6]

Function[edit]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660. 
  4. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  5. ^ Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C (Jun 2006). "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes". Arthritis Research & Therapy. 8 (3): R80. doi:10.1186/ar1946. PMC 1526623Freely accessible. PMID 16646978. 
  6. ^ a b "Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta)". 

Further reading[edit]