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Interleukin 36, beta
Symbols IL36B ; FIL1; FIL1-(ETA); FIL1H; FILI-(ETA); IL-1F8; IL-1H2; IL1-ETA; IL1F8; IL1H2
External IDs OMIM605508 MGI1916927 HomoloGene18278 GeneCards: IL36B Gene
RNA expression pattern
PBB GE IL1F8 gnf1h00165 at tn.png
PBB GE IL1F8 gnf1h02207 at tn.png
PBB GE IL1F8 gnf1h02208 at tn.png
More reference expression data
Species Human Mouse
Entrez 27177 69677
Ensembl ENSG00000136696 ENSMUSG00000026985
UniProt Q9NZH7 Q9D6Z6
RefSeq (mRNA) NM_014438 NM_027163
RefSeq (protein) NP_055253 NP_081439
Location (UCSC) Chr 2:
113.02 – 113.05 Mb
Chr 2:
24.15 – 24.16 Mb
PubMed search [1] [2]

Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.[1][2][3][4]


The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[4]


  1. ^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660. 
  2. ^ Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  3. ^ Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C (Jun 2006). "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes". Arthritis Research & Therapy 8 (3): R80. doi:10.1186/ar1946. PMC 1526623. PMID 16646978. 
  4. ^ a b "Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta)". 

Further reading[edit]