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Interleukin 36, gamma
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL36G ; IL-1F9; IL-1H1; IL-1RP2; IL1E; IL1F9; IL1H1; IL1RP2
External IDs OMIM605542 MGI2449929 HomoloGene49595 GeneCards: IL36G Gene
RNA expression pattern
PBB GE IL1F9 220322 at tn.png
More reference expression data
Species Human Mouse
Entrez 56300 215257
Ensembl ENSG00000136688 ENSMUSG00000044103
UniProt Q9NZH8 Q3U0P4
RefSeq (mRNA) NM_001278568 NM_153511
RefSeq (protein) NP_001265497 NP_705731
Location (UCSC) Chr 2:
112.97 – 112.99 Mb
Chr 2:
24.19 – 24.19 Mb
PubMed search [1] [2]

Interleukin-36 gamma also known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene.[1][2][3][4][5]


The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.[5]


  1. ^ Busfield SJ, Comrack CA, Yu G, Chickering TW, Smutko JS, Zhou H, Leiby KR, Holmgren LM, Gearing DP, Pan Y (Aug 2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666. 
  2. ^ Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR (May 2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J Biol Chem 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718. 
  3. ^ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722. 
  4. ^ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723. 
  5. ^ a b "Entrez Gene: IL1F9 interleukin 1 family, member 9". 

Further reading[edit]