IL2RA

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IL2RA
Protein IL2RA PDB 1z92.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
External IDs MGI: 96549 HomoloGene: 360 GeneCards: 3559
Genetically Related Diseases
Disease Name References
Rheumatoid Arthritis
diabetes mellitus type 1
multiple sclerosis
Crohn's disease
Alopecia areata
RNA expression pattern
PBB GE IL2RA 206341 at tn.png

PBB GE IL2RA 211269 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000417
NM_001308242
NM_001308243

NM_008367

RefSeq (protein)

NP_000408.1
NP_001295171.1
NP_001295172.1

NP_032393.3

Location (UCSC) Chr 10: 6.01 – 6.06 Mb Chr 2: 11.64 – 11.69 Mb
PubMed search [6] [7]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-2 receptor alpha chain is a protein that in humans is encoded by the IL2RA gene.[1]

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.[2]

Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.

References[edit]

  1. ^ Leonard WJ, Donlon TA, Lebo RV, Greene WC (Aug 1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science 228 (4707): 1547–9. doi:10.1126/science.3925551. PMID 3925551. 
  2. ^ "Entrez Gene: IL2RA interleukin 2 receptor, alpha". 

Further reading[edit]