From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
AliasesIL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin 31 receptor A
External IDsOMIM: 609510 MGI: 2180511 HomoloGene: 51395 GeneCards: IL31RA
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for IL31RA
Genomic location for IL31RA
Band5q11.2Start55,851,357 bp[1]
End55,922,854 bp[1]
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 5: 55.85 – 55.92 MbChr 13: 112.52 – 112.59 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.[5][6][7]

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164509 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050377 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (Jun 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896.
  6. ^ Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ (May 2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5". J Biol Chem. 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449.
  7. ^ a b "Entrez Gene: IL31RA interleukin 31 receptor A".

Further reading[edit]