IL3RA

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IL3RA
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin 3 receptor subunit alpha
External IDs MGI: 96553 HomoloGene: 48088 GeneCards: 3563
RNA expression pattern
PBB GE IL3RA 206148 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267713
NM_002183

NM_008369

RefSeq (protein)

NP_001254642.1
NP_002174.1

NP_032395.1

Location (UCSC) Chr X: 1.34 – 1.38 Mb Chr 14: 14.35 – 14.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.[1]

Function[edit]

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.[1]

Interactions[edit]

IL3RA has been shown to interact with Interleukin 3.[2][3]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.