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Interleukin 3 receptor, alpha (low affinity)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL3RA ; CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra
External IDs OMIM430000 MGI96553 HomoloGene48088 GeneCards: IL3RA Gene
RNA expression pattern
PBB GE IL3RA 206148 at tn.png
More reference expression data
Species Human Mouse
Entrez 3563 16188
Ensembl ENSG00000185291 ENSMUSG00000068758
UniProt P26951 P26952
RefSeq (mRNA) NM_001267713 NM_008369
RefSeq (protein) NP_001254642 NP_032395
Location (UCSC) Chr X:
1.34 – 1.38 Mb
Chr 14:
14.35 – 14.36 Mb
PubMed search [1] [2]

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.[1]


The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.[1]


IL3RA has been shown to interact with Interleukin 3.[2][3]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.