ILF2

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ILF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesILF2, NF45, PRO3063, interleukin enhancer binding factor 2
External IDsMGI: 1915031 HomoloGene: 26894 GeneCards: ILF2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ILF2
Genomic location for ILF2
Band1q21.3Start153,661,788 bp[1]
End153,671,028 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004515
NM_001267809

NM_026374

RefSeq (protein)

NP_001254738
NP_004506

NP_080650

Location (UCSC)Chr 1: 153.66 – 153.67 MbChr 3: 90.48 – 90.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[5][6]

Function[edit]

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[6]

Interactions[edit]

ILF2 has been shown to interact with CDC5L[7] and DNA-PKcs.[8]

ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus,[9][10] in canine systemic rheumatic autoimmune disease,[11][12] and as a rare finding in humans with autoimmune disease.[13]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143621 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001016 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (August 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry. 269 (32): 20691–9. PMID 7519613.
  6. ^ a b "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".
  7. ^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
  8. ^ Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
  9. ^ Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.
  10. ^ Kuroda Y, Ono N, Akaogi J, Nacionales DC, Yamasaki Y, Barker TT, Reeves WH, Satoh M (February 2006). "Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice". Toxicology. 218 (2–3): 186–96. doi:10.1016/j.tox.2005.10.011. PMID 16309812.
  11. ^ Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H (March 2018). "ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease". Scientific Reports. 8 (1): 4852. doi:10.1038/s41598-018-23034-w. PMC 5859008. PMID 29556082.
  12. ^ Hanna, Bremer (2018). Canine immune-mediated disease. Acta Universitatis agriculturae Sueciae. ISBN 978-91-7760-166-1.
  13. ^ Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.