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Interleukin enhancer binding factor 2
Symbols ILF2 ; NF45; PRO3063
External IDs OMIM603181 MGI1915031 HomoloGene26894 GeneCards: ILF2 Gene
Species Human Mouse
Entrez 3608 67781
Ensembl ENSG00000143621 ENSMUSG00000001016
UniProt Q12905 Q9CXY6
RefSeq (mRNA) NM_001267809 NM_026374
RefSeq (protein) NP_001254738 NP_080650
Location (UCSC) Chr 1:
153.66 – 153.67 Mb
Chr 3:
90.48 – 90.49 Mb
PubMed search [1] [2]

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[1][2]

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[2]


ILF2 has been shown to interact with CDC5L[3] and DNA-PKcs.[4]


  1. ^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthesy B (September 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". J Biol Chem 269 (32): 20691–9. PMID 7519613. 
  2. ^ a b "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa". 
  3. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 
  4. ^ Ting, N S; Kao P N; Chan D W; Lintott L G; Lees-Miller S P (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. (UNITED STATES) 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. ISSN 0021-9258. PMID 9442054. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.