ILF2

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ILF2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ILF2, NF45, PRO3063, interleukin enhancer binding factor 2
External IDs MGI: 1915031 HomoloGene: 26894 GeneCards: 3608
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004515
NM_001267809

NM_026374

RefSeq (protein)

NP_001254738.1
NP_004506.2

NP_080650.1

Location (UCSC) Chr 1: 153.66 – 153.67 Mb Chr 3: 90.48 – 90.49 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[3][4]

Function[edit]

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[4]

Interactions[edit]

ILF2 has been shown to interact with CDC5L[5] and DNA-PKcs.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (Aug 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry. 269 (32): 20691–9. PMID 7519613. 
  4. ^ a b "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa". 
  5. ^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846free to read. PMID 11101529. 
  6. ^ Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (Jan 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.