ILF3

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ILF3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ILF3, CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80, interleukin enhancer binding factor 3
External IDs MGI: 1339973 HomoloGene: 7785 GeneCards: 3609
Genetically Related Diseases
Disease Name References
obesity
RNA expression pattern
PBB GE ILF3 208930 s at tn.png

PBB GE ILF3 211375 s at tn.png

PBB GE ILF3 217805 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464

RefSeq (protein)

NP_001131145.1
NP_004507.2
NP_036350.2
NP_060090.2
NP_703194.1

NP_001036172.1
NP_001036173.1
NP_001264250.1
NP_001264251.1
NP_034691.2

Location (UCSC) Chr 19: 10.65 – 10.69 Mb Chr 9: 21.37 – 21.41 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.[1][2]

Function[edit]

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. At least three transcript variants encoding three different isoforms have been found for this gene.[3]

Interactions[edit]

ILF3 has been shown to interact with:

Small NF90/ILF3-associated RNAs (snaR) (~120 nucleotides long) and are known to interact with ILF3 double-stranded RNA-binding motifs.[12] snaR-A is abundant in human testis and has been shown to associate with ribosomes in HeLa cells. snaR-A is present in human and gorilla but not in chimpanzee. Other snaR RNAs are found in African Great Apes (including chimpanzee and bonobo).[13]

References[edit]

  1. ^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (Aug 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry 269 (32): 20691–9. PMID 7519613. 
  2. ^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Sep 1996). "Identification of novel M phase phosphoproteins by expression cloning". Molecular Biology of the Cell 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239. 
  3. ^ "Entrez Gene: ILF3 interleukin enhancer binding factor 3, 90kDa". 
  4. ^ Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (Jan 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry 273 (4): 2136–45. PMID 9442054. 
  5. ^ a b Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN (Aug 2001). "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR". The Journal of Biological Chemistry 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536. 
  6. ^ Tang J, Kao PN, Herschman HR (Jun 2000). "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3". The Journal of Biological Chemistry 275 (26): 19866–76. doi:10.1074/jbc.M000023200. PMID 10749851. 
  7. ^ Lee J, Bedford MT (Mar 2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays". EMBO Reports 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMC 1084016. PMID 11850402. 
  8. ^ Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367. 
  9. ^ Parker LM, Fierro-Monti I, Mathews MB (Aug 2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". The Journal of Biological Chemistry 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540. 
  10. ^ Patel RC, Vestal DJ, Xu Z, Bandyopadhyay S, Guo W, Erme SM, Williams BR, Sen GC (Jul 1999). "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR". The Journal of Biological Chemistry 274 (29): 20432–7. PMID 10400669. 
  11. ^ Brownawell AM, Macara IG (Jan 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". The Journal of Cell Biology 156 (1): 53–64. doi:10.1083/jcb.200110082. PMC 2173575. PMID 11777942. 
  12. ^ Parrott AM, Mathews MB (2007). "Novel rapidly evolving hominid RNAs bind nuclear factor 90 and display tissue-restricted distribution". Nucleic Acids Research 35 (18): 6249–58. doi:10.1093/nar/gkm668. PMID 17855395. 
  13. ^ Parrott AM, Tsai M, Batchu P, Ryan K, Ozer HL, Tian B, Mathews MB (Mar 2011). "The evolution and expression of the snaR family of small non-coding RNAs". Nucleic Acids Research 39 (4): 1485–500. doi:10.1093/nar/gkq856. PMID 20935053. 

Further reading[edit]

  • St Johnston D, Brown NH, Gall JG, Jantsch M (Nov 1992). "A conserved double-stranded RNA-binding domain". Proceedings of the National Academy of Sciences of the United States of America 89 (22): 10979–83. doi:10.1073/pnas.89.22.10979. PMC 50466. PMID 1438302. 
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  • Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (Jan 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054. 
  • Marcoulatos P, Avgerinos E, Tsantzalos DV, Vamvakopoulos NC (May 1998). "Mapping interleukin enhancer binding factor 3 gene (ILF3) to human chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates". Journal of Interferon & Cytokine Research 18 (5): 351–5. doi:10.1089/jir.1998.18.351. PMID 9620363. 
  • Aoki Y, Zhao G, Qiu D, Shi L, Kao PN (Dec 1998). "CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku". The American Journal of Physiology 275 (6 Pt 1): L1164–72. PMID 9843854. 
  • Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367. 
  • Patel RC, Vestal DJ, Xu Z, Bandyopadhyay S, Guo W, Erme SM, Williams BR, Sen GC (Jul 1999). "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR". The Journal of Biological Chemistry 274 (29): 20432–7. doi:10.1074/jbc.274.29.20432. PMID 10400669. 
  • Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (Dec 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923. 
  • Xu YH, Grabowski GA (Dec 1999). "Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs". Molecular Genetics and Metabolism 68 (4): 441–54. doi:10.1006/mgme.1999.2934. PMID 10607473. 
  • Coolidge CJ, Patton JG (Mar 2000). "A new double-stranded RNA-binding protein that interacts with PKR". Nucleic Acids Research 28 (6): 1407–17. doi:10.1093/nar/28.6.1407. PMC 111047. PMID 10684936. 
  • Tang J, Kao PN, Herschman HR (Jun 2000). "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3". The Journal of Biological Chemistry 275 (26): 19866–76. doi:10.1074/jbc.M000023200. PMID 10749851. 
  • Saunders LR, Jurecic V, Barber GN (Jan 2001). "The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13". Genomics 71 (2): 256–9. doi:10.1006/geno.2000.6423. PMID 11161820. 
  • Duchange N, Pidoux J, Camus E, Sauvaget D (Dec 2000). "Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene". Gene 261 (2): 345–53. doi:10.1016/S0378-1119(00)00495-9. PMID 11167023. 
  • Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN (Aug 2001). "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR". The Journal of Biological Chemistry 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536. 
  • Parker LM, Fierro-Monti I, Mathews MB (Aug 2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". The Journal of Biological Chemistry 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540. 
  • Reichman TW, Muñiz LC, Mathews MB (Jan 2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Molecular and Cellular Biology 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.