IMPDH2

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IMPDH2
PDB 1b3o EBI.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIMPDH2, IMPD2, IMPDH-II, IMP (inosine 5'-monophosphate) dehydrogenase 2, inosine monophosphate dehydrogenase 2
External IDsMGI: 109367 HomoloGene: 48919 GeneCards: IMPDH2
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for IMPDH2
Genomic location for IMPDH2
Band3p21.31Start49,024,325 bp[1]
End49,029,408 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000884

NM_011830

RefSeq (protein)

NP_000875

NP_035960

Location (UCSC)Chr 3: 49.02 – 49.03 MbChr 9: 108.56 – 108.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.[5][6][7]

Function[edit]

IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.[5] IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A[8]

Clinical significance[edit]

This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178035 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062867 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b c "Entrez Gene: IMP (inosine monophosphate) dehydrogenase 2". 
  6. ^ Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K (March 1990). "Two distinct cDNAs for human IMP dehydrogenase". J. Biol. Chem. 265 (9): 5292–5. PMID 1969416. 
  7. ^ Kost-Alimova MV, Glesne DA, Huberman E, Zelenin AV (1998). "Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 145–6. doi:10.1159/000015088. PMID 9858805. 
  8. ^ Pua KH, Stiles DT, Sowa ME, Verdine GL (10 January 2017). "IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex". Cell Rep. 18 (2): 432–442. doi:10.1016/j.celrep.2016.12.030. PMID 28076787. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.