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The mnemonic is interpreted as:
- Illness - Is the pilot suffering from any illness or symptom of an illness which might affect them in flight,
- Medication - Is the pilot currently taking any drugs (prescription or over-the-counter),
- Stress - Psychological or emotional factors which might affect the pilot's performance,
- Alcohol - Although legal limits vary by jurisdiction (20 mg/mL blood in the UK,(0.04 or greater in the USA) one quarter that for driving), the pilot might want to consider their alcohol consumption within the last 8 to 24 hours,
- Fatigue - Has the pilot had sufficient sleep and rest in the recent past, and
- Eating - Is the pilot sufficiently nourished?
Some sources  give the Emotion.
- "Flight Fitness: The "I'm Safe" Checklist". FAA Medical Certification. Pilot Medical Solutions, Incorporated. Retrieved 20 December 2011.
- Implementation of the Railways and Transport Safety Act 2003, section 2.3
- FAA Risk Management Handbook FAA-H-8083-2 uses "Eating" on the title page of Chapter 3, and "Emotion" in Figure 3-3, two pages hence.
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