ING3

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ING3
Protein ING3 PDB 1x4i.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesING3, Eaf4, ING2, MEAF4, p47inhibitor of growth family member 3
External IDsMGI: 1919027 HomoloGene: 6804 GeneCards: ING3
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ING3
Genomic location for ING3
Band7q31.31Start120,950,749 bp[1]
End120,977,216 bp[1]
RNA expression pattern
PBB GE ING3 205070 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198267
NM_019071
NM_198266

NM_023626
NM_001311061

RefSeq (protein)

NP_061944
NP_938008

NP_001297990
NP_076115

Location (UCSC)Chr 7: 120.95 – 120.98 MbChr 6: 21.95 – 21.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inhibitor of growth protein 3 is a protein that in humans is encoded by the ING3 gene.[5][6]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000071243 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029670 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi:10.1038/sj.onc.1205540. PMID 12080476.
  6. ^ a b "Entrez Gene: ING3 inhibitor of growth family, member 3".

Further reading[edit]