INHA

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INHA
Identifiers
Aliases INHA, inhibin alpha subunit, inhibin subunit alpha
External IDs MGI: 96569 HomoloGene: 1652 GeneCards: INHA
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for INHA
Genomic location for INHA
Band 2q35 Start 219,569,162 bp[1]
End 219,575,713 bp[1]
RNA expression pattern
PBB GE INHA 210141 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002191

NM_010564
NM_001329843

RefSeq (protein)

NP_002182

NP_001316772
NP_034694

Location (UCSC) Chr 2: 219.57 – 219.58 Mb Chr 1: 75.51 – 75.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.[5]

Function[edit]

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123999 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032968 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731. 
  6. ^ "Entrez Gene: INHA inhibin, alpha". 

Further reading[edit]