INPP5B

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INPP5B
Protein INPP5B PDB 3MTC.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases INPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDs MGI: 103257 HomoloGene: 69021 GeneCards: INPP5B
RNA expression pattern
PBB GE INPP5B 213643 s at fs.png

PBB GE INPP5B 213804 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001297434
NM_005540
NM_001350227
NM_001350228

NM_008385

RefSeq (protein)

NP_001284363
NP_005531

NP_032411.3
NP_032411

Location (UCSC) Chr 1: 37.86 – 37.95 Mb Chr 4: 124.74 – 124.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.[3][4]

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. PMID 1718960. 
  4. ^ a b "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa". 

Further reading[edit]