INSM1

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INSM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesINSM1, IA-1, IA1, INSM transcriptional repressor 1
External IDsMGI: 1859980 HomoloGene: 31080 GeneCards: INSM1
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for INSM1
Genomic location for INSM1
Band20p11.23Start20,368,121 bp[1]
End20,370,949 bp[1]
RNA expression pattern
PBB GE INSM1 206502 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002196

NM_016889

RefSeq (protein)

NP_002187

NP_058585

Location (UCSC)Chr 20: 20.37 – 20.37 MbChr 2: 146.22 – 146.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[5][6][7]

Function[edit]

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[7] [8]

Interactions[edit]

INSM1 has been shown to interact with SORBS1.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173404 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068154 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lan MS, Li Q, Lu J, Modi WS, Notkins AL (May 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". The Journal of Biological Chemistry. 269 (19): 14170–4. PMID 8188699.
  6. ^ Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (July 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". The Biochemical Journal. 397 (1): 169–77. doi:10.1042/BJ20051669. PMC 1479746. PMID 16569215.
  7. ^ a b "Entrez Gene: INSM1 insulinoma-associated 1".
  8. ^ Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF (August 2018). "Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections". Modern Pathology. Epub ahead of print. doi:10.1038/s41379-018-0122-7. PMID 30154579.
  9. ^ Xie J, Cai T, Zhang H, Lan MS, Notkins AL (July 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.

Further reading[edit]