INSM1

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INSM1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases INSM1, IA-1, IA1, INSM transcriptional repressor 1
External IDs MGI: 1859980 HomoloGene: 31080 GeneCards: INSM1
RNA expression pattern
PBB GE INSM1 206502 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002196

NM_016889

RefSeq (protein)

NP_002187

NP_058585.2
NP_058585

Location (UCSC) Chr 20: 20.37 – 20.37 Mb Chr 2: 146.22 – 146.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[3][4][5]

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[5]

Interactions[edit]

INSM1 has been shown to interact with SORBS1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lan MS, Li Q, Lu J, Modi WS, Notkins AL (Jun 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". J Biol Chem. 269 (19): 14170–4. PMID 8188699. 
  4. ^ Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (Jun 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". Biochem J. 397 (1): 169–77. doi:10.1042/BJ20051669. PMC 1479746Freely accessible. PMID 16569215. 
  5. ^ a b "Entrez Gene: INSM1 insulinoma-associated 1". 
  6. ^ Xie, Jingping; Cai Tao; Zhang Honglai; Lan Michael S; Notkins Abner Louis (Jul 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. United States. 80 (1): 54–61. doi:10.1006/geno.2002.6800. ISSN 0888-7543. PMC 1237014Freely accessible. PMID 12079283. 

Further reading[edit]