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IOI may refer to:
- Idiopathic orbital inflammatory disease
- International Olympiad in Informatics
- Interonset interval
- Indication of Interest, used in financial trading
- Interest on Investment, a synonym for Return on Investment (ROI)
- IO Interactive, a Danish video game developer
- International Ombudsman Institute
- IOI Group, a Malaysian conglomerate
- I.O.I, a South Korean girl group formed from the television show Produce 101
- Innovative Online Industries (IOI), the fictional corporation that employs most of the antagonists of the 2011 novel Ready Player One and its 2018 film adaptation.
| disambiguation page lists articles associated with the title IOI.
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