IRAK2

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Interleukin-1 receptor-associated kinase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IRAK2 ; IRAK-2
External IDs OMIM603304 MGI2429603 HomoloGene1207 GeneCards: IRAK2 Gene
RNA expression pattern
PBB GE IRAK2 gnf1h00036 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3656 108960
Ensembl ENSG00000134070 ENSMUSG00000060477
UniProt O43187 Q8CFA1
RefSeq (mRNA) NM_001570 NM_001113553
RefSeq (protein) NP_001561 NP_001107025
Location (UCSC) Chr 3:
10.16 – 10.24 Mb
Chr 6:
113.64 – 113.7 Mb
PubMed search [1] [2]

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[1][2]

Function[edit]

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[2]

Interactions[edit]

IRAK2 has been shown to interact with TRAF6[1][3] and Myd88.[1][3][4]

References[edit]

  1. ^ a b c Muzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458. 
  2. ^ a b "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2". 
  3. ^ a b Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454. 
  4. ^ Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529. 

Further reading[edit]

  • Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews 9 (3-4): 221–37. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122. 
  • Maschera B, Ray K, Burns K, Volpe F (Apr 1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". The Biochemical Journal. 339 ( Pt 2) (2): 227–31. doi:10.1042/0264-6021:3390227. PMC 1220149. PMID 10191251. 
  • Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454. 
  • Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529. 
  • McDermott EP, O'Neill LA (Mar 2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1". The Journal of Biological Chemistry 277 (10): 7808–15. doi:10.1074/jbc.M108133200. PMID 11744690. 
  • Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773. 
  • Bin LH, Xu LG, Shu HB (Jul 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283. 
  • Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593. 
  • Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination". The Journal of Biological Chemistry 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.