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interleukin-1 receptor-associated kinase 4
Symbol IRAK4
Entrez 51135
HUGO 17967
OMIM 606883
RefSeq NM_016123
UniProt Q9NWZ3
Other data
Locus Chr. 12 q12

IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors.

Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

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