|interleukin-1 receptor-associated kinase 4|
|Locus||Chr. 12 q12|
IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors.
Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.
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