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Interferon regulatory factor 2
Protein IRF2 PDB 1irf.png
PDB rendering based on 1irf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IRF2 ; IRF-2
External IDs OMIM147576 MGI96591 HomoloGene1659 GeneCards: IRF2 Gene
RNA expression pattern
PBB GE IRF2 203275 at tn.png
More reference expression data
Species Human Mouse
Entrez 3660 16363
Ensembl ENSG00000168310 ENSMUSG00000031627
UniProt P14316 P23906
RefSeq (mRNA) NM_002199 NM_008391
RefSeq (protein) NP_002190 NP_032417
Location (UCSC) Chr 4:
184.39 – 184.47 Mb
Chr 8:
46.74 – 46.85 Mb
PubMed search [1] [2]

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[1]


IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[2]

See also[edit]


IRF2 has been shown to interact with BRD7,[3] EP300[4] and PCAF.[4][5]


  1. ^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell 58 (4): 729–39. doi:10.1016/0092-8674(89)90107-4. PMID 2475256. 
  2. ^ "Entrez Gene: IRF2 interferon regulatory factor 2". 
  3. ^ Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449. 
  4. ^ a b Masumi A, Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. doi:10.1074/jbc.M101707200. PMID 11304541. 
  5. ^ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. PMC 83974. PMID 10022868. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.