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Interferon regulatory factor 5
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IRF5 ; SLEB10
External IDs OMIM607218 MGI1350924 HomoloGene8088 GeneCards: IRF5 Gene
RNA expression pattern
PBB GE IRF5 205469 s at tn.png
PBB GE IRF5 205468 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3663 27056
Ensembl ENSG00000128604 ENSMUSG00000029771
UniProt Q13568 P56477
RefSeq (mRNA) NM_001098627 NM_001252382
RefSeq (protein) NP_001092097 NP_001239311
Location (UCSC) Chr 7:
128.94 – 128.95 Mb
Chr 6:
29.53 – 29.54 Mb
PubMed search [1] [2]

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene.[1]


IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.[1]

Clinical significance[edit]

IRF5 acts as a molecular switch that controls whether macrophages will promote or inhibit inflammation. Blocking the production of IRF5 in macrophages may help treat a wide range of autoimmune diseases, and that boosting IRF5 levels might help treat people whose immune systems are weak, compromised, or damaged. IRF5 seems to work "either by interacting with DNA directly, or by interacting with other proteins that themselves control which genes are switched on."[2]

See also[edit]


  1. ^ a b "Entrez Gene: IRF5 interferon regulatory factor 5". 
  2. ^ Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M, Udalova IA (January 2011). "IRF5 promotes inflammatory macrophage polarization and T(H)1-T(H)17 responses". Nat Immunol 12 (3): 231–238. doi:10.1038/ni.1990. PMID 21240265. Lay summaryMedScape. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.