IRGM

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IRGM
Identifiers
AliasesIRGM, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M, immunity related GTPase M
External IDsOMIM: 608212 MGI: 1926262 HomoloGene: 78363 GeneCards: IRGM
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for IRGM
Genomic location for IRGM
Band5q33.1Start150,846,523 bp[1]
End150,900,736 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145805
NM_001346557

NM_019440

RefSeq (protein)

NP_001139277
NP_001333486

n/a

Location (UCSC)Chr 5: 150.85 – 150.9 MbChr 11: 58.2 – 58.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene.[5]

IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.

Clinical relevance[edit]

Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000237693 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069874 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: immunity-related GTPase family".
  6. ^ Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease" (PDF). Hum. Mol. Genet. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.