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Aliases IRS4, IRS-4, PY160, insulin receptor substrate 4
External IDs HomoloGene: 136777 GeneCards: IRS4
RNA expression pattern
PBB GE IRS4 207403 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 108.73 – 108.74 Mb n/a
PubMed search [1] n/a
View/Edit Human

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.[2][3][4]

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.[4]


IRS4 has been shown to interact with CRK[5][6] and NISCH.[7]


  1. ^ "Human PubMed Reference:". 
  2. ^ Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family". J Biol Chem. 272 (34): 21403–7. doi:10.1074/jbc.272.34.21403. PMID 9261155. 
  3. ^ Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells". J Biol Chem. 273 (17): 10726–32. doi:10.1074/jbc.273.17.10726. PMID 9553137. 
  4. ^ a b "Entrez Gene: IRS4 insulin receptor substrate 4". 
  5. ^ Karas, M; Koval A P; Zick Y; LeRoith D (May 2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology. United States. 142 (5): 1835–40. doi:10.1210/en.142.5.1835. ISSN 0013-7227. PMID 11316748. 
  6. ^ Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction". J. Biol. Chem. UNITED STATES. 273 (24): 14780–7. doi:10.1074/jbc.273.24.14780. ISSN 0021-9258. PMID 9614078. 
  7. ^ Sano, Hiroyuki; Liu Simon C H; Lane William S; Piletz John E; Lienhard Gustav E (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. United States. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. ISSN 0021-9258. PMID 11912194. 

Further reading[edit]