IRX2

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IRX2
Identifiers
AliasesIRX2, IRXA2, iroquois homeobox 2
External IDsMGI: 1197526 HomoloGene: 56490 GeneCards: IRX2
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for IRX2
Genomic location for IRX2
Band5p15.33Start2,745,845 bp[1]
End2,751,677 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134222
NM_033267

NM_010574

RefSeq (protein)

NP_001127694
NP_150366

NP_034704

Location (UCSC)Chr 5: 2.75 – 2.75 MbChr 13: 72.63 – 72.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.[5][6]

Function[edit]

IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[5]

Cancer[edit]

IRX2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [7] For this reason, IRX2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. [7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170561 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001504 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: iroquois homeobox 2".
  6. ^ Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706.
  7. ^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1001/jamadermatol.2018.1373. PMID 25205602.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.