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ISTC may refer to:
- Incunabula Short Title Catalogue
- Independent Sector Treatment Centre, part of the UK National Health Service
- Institute of Scientific and Technical Communicators
- International Science and Technology Center
- International Space Training Center, the fictional institution behind Mission: Space ride at Epcot
- International Standard Text Code, a numeric code in development by the ISO for textual works
- International Student Travel Confederation
- The former Iron and Steel Trades Confederation trade union, now part of Community (trade union)
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