ITGA11

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ITGA11
Identifiers
Aliases ITGA11, HsT18964, integrin subunit alpha 11
External IDs MGI: 2442114 HomoloGene: 8151 GeneCards: ITGA11
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for ITGA11
Genomic location for ITGA11
Band 15q23 Start 68,296,533 bp[1]
End 68,432,162 bp[1]
RNA expression pattern
PBB GE ITGA11 gnf1h00121 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004439
NM_012211

NM_176922

RefSeq (protein)

NP_001004439

n/a

Location (UCSC) Chr 15: 68.3 – 68.43 Mb Chr 15: 62.68 – 62.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.[5][6]

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.[6]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137809 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032243 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, Liu D, Wang SX, Morris CM, Krissansen GW (Nov 1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)". Genomics. 60 (2): 179–87. PMID 10486209. doi:10.1006/geno.1999.5909. 
  6. ^ a b "Entrez Gene: ITGA11 integrin, alpha 11". 
  7. ^ Byström B, Carracedo S, Behndig AB, Gullberg D, Pedrosa-Domellof F (June 2009). "{alpha}11 integrin in the human cornea-importance in development and disease". Invest. Ophthalmol. Vis. Sci. 50 (11): 5044–53. PMID 19516006. doi:10.1167/iovs.08-3261. 

Further reading[edit]

External links[edit]