ITGA11

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ITGA11
Identifiers
Aliases ITGA11, HsT18964, integrin subunit alpha 11
External IDs MGI: 2442114 HomoloGene: 8151 GeneCards: 22801
Genetically Related Diseases
Disease Name References
major depressive disorder
attention deficit hyperactivity disorder
RNA expression pattern
PBB GE ITGA11 gnf1h00121 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004439
NM_012211

NM_176922

RefSeq (protein)

NP_001004439.1

n/a

Location (UCSC) Chr 15: 68.3 – 68.43 Mb Chr 9: 62.68 – 62.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.[1][2]

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.[2]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.[3]

References[edit]

  1. ^ Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, Liu D, Wang SX, Morris CM, Krissansen GW (Nov 1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)". Genomics 60 (2): 179–87. doi:10.1006/geno.1999.5909. PMID 10486209. 
  2. ^ a b "Entrez Gene: ITGA11 integrin, alpha 11". 
  3. ^ Byström B, Carracedo S, Behndig AB, Gullberg D, Pedrosa-Domellof F (June 2009). "{alpha}11 integrin in the human cornea-importance in development and disease". Invest. Ophthalmol. Vis. Sci. 50 (11): 5044–53. doi:10.1167/iovs.08-3261. PMID 19516006. 

Further reading[edit]

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