Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2Bgene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
^Kato, Atsushi; Kawamata Norihiko; Tamayose Kenji; Egashira Motoki; Miura Rika; Fujimura Tsutomu; Murayama Kimie; Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. United States. 277 (32): 28934–41. doi:10.1074/jbc.M204340200. ISSN0021-9258. PMID12042322.