ITGA6

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ITGA6
Identifiers
Aliases ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6
External IDs MGI: 96605 HomoloGene: 20091 GeneCards: 3655
Genetically Related Diseases
Disease Name References
prostate cancer
RNA expression pattern
PBB GE ITGA6 201656 at tn.png

PBB GE ITGA6 215177 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000210
NM_001079818
NM_001316306

NM_001277970
NM_008397

RefSeq (protein)

NP_000201.2
NP_001073286.1
NP_001303235.1

NP_001264899.1

Location (UCSC) Chr 2: 172.43 – 172.51 Mb Chr 2: 71.75 – 71.86 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function[edit]

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[1]

Interactions[edit]

ITGA6 has been shown to interact with TSPAN4[2] and GIPC1.[3]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: ITGA6 integrin, alpha 6". 
  2. ^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996. 
  3. ^ Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315. 

Further reading[edit]

  • Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer Metastasis Reviews 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729. 

External links[edit]