Integrin alpha 9

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AliasesITGA9, ALPHA-RLC, ITGA4L, RLC, integrin subunit alpha 9
External IDsMGI: 104756 HomoloGene: 1664 GeneCards: ITGA9
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ITGA9
Genomic location for ITGA9
Band3p22.2Start37,452,115 bp[1]
End37,823,507 bp[1]
RNA expression pattern
PBB GE ITGA9 gnf1h04097 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 37.45 – 37.82 MbChr 9: 118.61 – 118.9 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene.[5][6][7] Cytogenetic location: 3p22.2 [8]


This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for tenascin-C, VCAM1 and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.[7]


The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell adhesion with various ligands in the extracellular matrix (ECM), including extra domain A (EDA) fibronectin, tenascin-C, ADAMs, EMELIN1, osteopontin, and VEGF.[9] α9β1 binding is independent of the RGD peptide sequence.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144668 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039115 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D (Jan 1994). "Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle". J Cell Biol. 123 (5): 1289–97. doi:10.1083/jcb.123.5.1289. PMC 2119880. PMID 8245132.
  6. ^ Hibi K, Yamakawa K, Ueda R, Horio Y, Murata Y, Tamari M, Uchida K, Takahashi T, Nakamura Y, Takahashi T (Feb 1994). "Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer". Oncogene. 9 (2): 611–9. PMID 8290272.
  7. ^ a b "Entrez Gene: ITGA9 integrin, alpha 9".
  8. ^ Sulimova G, Kutsenko A, Rakhmanaliev E, Udina I, Kompaniytsev A, Protopopov A, Moisjak E, Klimov E, Muravenko O, Zelenin A, Braga E, Kashuba V, Zabarovsky E, Kisselev L (2002). "Human chromosome 3: integration of 60 NotI clones into a physical and gene map". Cytogenetic and Genome Research. 98: 177–183. doi:10.1159/000069814.
  9. ^ Høye AM, Couchman JR, Wewer UM, Fukami K, Yoneda A (May 2012). "The newcomer in the integrin family: integrin α9 in biology and cancer". Advances in biological regulation. 52 (2): 326–39. doi:10.1016/j.jbior.2012.03.004. PMID 22781746.

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