Integrin alpha-V is a protein that in humans is encoded by the ITGAVgene.
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
University of Edinburgh. (2013, November 10). Hope for transplant patients as study finds key to organ scarring. ScienceDaily. Retrieved December 2, 2014 from www.sciencedaily.com/releases/2013/11/131110184408.htm