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Integrin, alpha V
PDB 1jv2 EBI.jpg
Rendering of 1JV2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ITGAV ; CD51; MSK8; VNRA; VTNR
External IDs OMIM193210 MGI96608 HomoloGene20510 ChEMBL: 3660 GeneCards: ITGAV Gene
RNA expression pattern
PBB GE ITGAV 202351 at tn.png
More reference expression data
Species Human Mouse
Entrez 3685 16410
Ensembl ENSG00000138448 ENSMUSG00000027087
UniProt P06756 P43406
RefSeq (mRNA) NM_001144999 NM_008402
RefSeq (protein) NP_001138471 NP_032428
Location (UCSC) Chr 2:
186.59 – 186.68 Mb
Chr 2:
83.72 – 83.81 Mb
PubMed search [1] [2]

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.[1]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[2]

See also[edit]


  1. ^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS; et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952. 
  2. ^ "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)". 

Further reading[edit]

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