Intelectin-1

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ITLN1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDs MGI: 1333831 HomoloGene: 111044 GeneCards: ITLN1
Genetically Related Diseases
Crohn's disease[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017625

NM_010584

RefSeq (protein)

NP_060095

NP_034714.1
NP_034714

Location (UCSC) Chr 1: 160.88 – 160.89 Mb Chr 1: 171.52 – 171.54 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.[4][5][6] Intelectin-1 functions both as a receptor for bacterial arabinogalactans[4] and for lactoferrin.[7]

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.[8][9]

See also[edit]

References[edit]

  1. ^ "Diseases that are genetically associated with ITLN1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (Jun 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". J Biol Chem. 276 (26): 23456–63. doi:10.1074/jbc.M103162200. PMID 11313366. 
  5. ^ Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (Feb 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi:10.1093/glycob/11.1.65. PMID 11181563. 
  6. ^ "Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)". 
  7. ^ Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID 11747454. 
  8. ^ Wesener, Darryl A; Wangkanont, Kittikhun; McBride, Ryan; Song, Xuezheng; Kraft, Matthew B; Hodges, Heather L; Zarling, Lucas C; Splain, Rebecca A; Smith, David F; Cummings, Richard D; Paulson, James C; Forest, Katrina T; Kiessling, Laura L (6 July 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–610. doi:10.1038/nsmb.3053. PMC 4526365Freely accessible. PMID 26148048. 
  9. ^ Wangkanont, K; Wesener, DA; Vidani, JA; Kiessling, LL; Forest, KT (11 January 2016). "Structures of Xenopus embryonic epidermal lectin reveal a conserved mechanism of microbial glycan recognition.". The Journal of Biological Chemistry. 291: 5596–610. doi:10.1074/jbc.M115.709212. PMID 26755729. 

Further reading[edit]