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Integral membrane protein 2B
Symbols ITM2B ; ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; RDGCA; imBRI2
External IDs OMIM603904 MGI1309517 HomoloGene7388 GeneCards: ITM2B Gene
RNA expression pattern
PBB GE ITM2B 217732 s at tn.png
PBB GE ITM2B 217731 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9445 16432
Ensembl ENSG00000136156 ENSMUSG00000022108
UniProt Q9Y287 O89051
RefSeq (mRNA) NM_021999 NM_008410
RefSeq (protein) NP_068839 NP_032436
Location (UCSC) Chr 13:
48.23 – 48.27 Mb
Chr 14:
73.36 – 73.39 Mb
PubMed search [1] [2]

Integral membrane protein 2B (ITM2B or BRI2) is a protein that in humans is encoded by the ITM2B gene.[1][2]

ITM2B or BRI2 is a gene located on chromosome 13. The gene is connected to familial Danish dementia and familial British dementia causing amyloid and pre-filbrillar effects similar to those seen in Alzheimer's.


  1. ^ Pittois K, Deleersnijder W, Merregaert J (Nov 1998). "cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B". Gene 217 (1-2): 141–9. doi:10.1016/S0378-1119(98)00354-0. PMID 9795190. 
  2. ^ "Entrez Gene: ITM2B integral membrane protein 2B". 

Further reading[edit]