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Inositol 1,4,5-trisphosphate receptor, type 3
Symbols ITPR3 ; IP3R; IP3R3
External IDs OMIM147267 MGI96624 HomoloGene1675 IUPHAR: 745 ChEMBL: 3904 GeneCards: ITPR3 Gene
Species Human Mouse
Entrez 3710 16440
Ensembl ENSG00000096433 ENSMUSG00000042644
UniProt Q14573 P70227
RefSeq (mRNA) NM_002224 NM_080553
RefSeq (protein) NP_002215 NP_542120
Location (UCSC) Chr 6:
33.62 – 33.7 Mb
Chr 17:
27.06 – 27.12 Mb
PubMed search [1] [2]

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.[1] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.[2]


ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.[3]

See also[edit]


  1. ^ "Entrez Gene: inositol 1". 
  2. ^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels 2 (1): 9–22. PMID 8081734. 
  3. ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655. PMID 20696704. 

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