ITPR3

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ITPR3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
External IDs MGI: 96624 HomoloGene: 1675 GeneCards: 3710
Genetically Related Diseases
Disease Name References
morbid obesity
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002224

NM_080553

RefSeq (protein)

NP_002215.2

NP_542120.2

Location (UCSC) Chr 6: 33.62 – 33.7 Mb Chr 17: 27.06 – 27.12 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.[4] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.[5]

Function[edit]

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.[6]

See also[edit]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_11981&geneId=80412". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: inositol 1". 
  5. ^ Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels. 2 (1): 9–22. PMID 8081734. 
  6. ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655free to read. PMID 20696704. 

Further reading[edit]

External links[edit]