Intersectin 1

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Protein ITSN1 PDB 1ki1.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesITSN1, ITSN, SH3D1A, SH3P17, intersectin 1
External IDsOMIM: 602442 MGI: 1338069 HomoloGene: 2277 GeneCards: ITSN1
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for ITSN1
Genomic location for ITSN1
Band21q22.11Start33,642,400 bp[1]
End33,899,861 bp[1]
RNA expression pattern
PBB GE ITSN1 207322 at fs.png

PBB GE ITSN1 35776 at fs.png

PBB GE ITSN1 209297 at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 21: 33.64 – 33.9 MbChr 16: 91.73 – 91.92 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.[5][6]


The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.[7]


ITSN1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205726 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022957 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Guipponi M, Scott HS, Chen H, Schebesta A, Rossier C, Antonarakis SE (Nov 1998). "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon". Genomics. 53 (3): 369–76. doi:10.1006/geno.1998.5521. PMID 9799604.
  6. ^ Yamabhai M, Hoffman NG, Hardison NL, McPherson PS, Castagnoli L, Cesareni G, Kay BK (Nov 1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". The Journal of Biological Chemistry. 273 (47): 31401–7. doi:10.1074/jbc.273.47.31401. PMID 9813051.
  7. ^ "Entrez Gene: ITSN1 intersectin 1 (SH3 domain protein)".
  8. ^ Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS (Oct 2001). "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP". Nature Cell Biology. 3 (10): 927–32. doi:10.1038/ncb1001-927. PMID 11584276.
  9. ^ Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984.
  10. ^ Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (Apr 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
  11. ^ Okamoto M, Schoch S, Südhof TC (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?". The Journal of Biological Chemistry. 274 (26): 18446–54. doi:10.1074/jbc.274.26.18446. PMID 10373452.
  12. ^ Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal. 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. PMC 305667. PMID 10716926.

Further reading[edit]