I Against I was formed by two childhood friends, Ronald van Maren and Jasper Blazer, in the mid-1990s in the Netherlands. Their name comes from the Bad Brains record, I Against I. They signed to Epitaph Records in 1996, the first European group to do so. An EP followed in 1997 and a full-length in 1998 called Headcleaner, which was recorded in "the Blastingroom" in Fort Collins, Colorado, the studio of Bill Stevenson of All. The group toured Europe and played South by Southwest in 1998. Their sophomore LP titled "i'm a fucked up dancer but my moods are swinging" followed on Epitaph in 1999, but was released only in Europe. During this time the group toured with, Down by Law, All, and played with several bands like Bad Religion, Pennywise, No Fun At All, Blink 182, Dog Eat Dog, Shelter and the Bouncing Souls. In 2002, the group left Epitaph and released five songs on a split with MadBones on Ammonia Records which was intended as a demo only, but the label liked the five songs enough to officially release them and send the band on tour in Italy, Germany and Belgium. Finally they released a self-titled LP in 2005 on Moondown Records mixed once again by Bill Stevenson and Jason Livermore.
In November 2008, the band announced that they are calling it quits because "time has come to pursue other things".