Igor Stagljar

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Igor Stagljar
Igor Stagljar 2014.jpg
Born (1966-04-17) April 17, 1966 (age 53)
NationalityFlag of Croatia.svg Croat Flag of Canada.svg Canadian
Alma materFaculty of Science, University of Zagreb[1]
Scientific career
FieldsMolecular biology
InstitutionsUniversity of Toronto

Igor Stagljar (born April 17, 1966) is a Croatian-Canadian molecular biologist[2] and one of the world leaders in the field of proteomics and systems biology. He received a B.A. (1990) from the University of Zagreb (Croatia), and a Ph.D. (1994) in molecular biology from ETH Zurich (Switzerland).[3]

Igor Stagljar is probably best known for the development of the split-ubiquitin Membrane Yeast Two-Hybrid (MYTH)[4] and Mammalian Membrane Two-Hybrid technologies,[5] powerful tools for the identification of proteins associated with proteins that are localized to various cellular membranes. This has led to many groundbreaking discoveries and the elucidation of functions of various membrane proteins involved in human health and disease.[6][7][8][9][10][11]

Igor Stagljar is Professor of Molecular Genetics and Biochemistry at Donnelly Centre (CCBR) at the Medical School of the University of Toronto. He is a co-founder of Dualsystems Biotech Inc, one of the world-leading companies in the field of interactive proteomics.


  1. ^ http://arhiva.nacional.hr/clanak/33924/igor-stagljar-hrvatski-znanstvenik-otkriva-tajnu-bolesti ‹See Tfd›(in Croatian)
  2. ^ http://canadianimmigrant.ca/work-and-education/croatian-born-molecular-biologist-works-hard-and-plays-hard-in-canada
  3. ^ http://www.croatia.org/crown/articles/9835/1/Igor-Stagljar-distinguished-Croatian-molecular-biologist-in-Toronto)
  4. ^ Stagljar, I., Korostensky, C., Johnsson, N. and te Heesen, S. (1998) A new genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo. Proc. Natl. Acad. Sci. USA 95, 5187-5192.
  5. ^ Petschnigg, J., Groisman, B., Kotlyar, M., Taipale, M., Zheng, Y., Kurat, C.F., Sayad, A., J. Rafael Sierra, Mattiazzi Usaj, M., Snider, J., Nachman, A., Krykbaeva, I., Tsao, M-S., Moffat, J., Pawson, T., Lindquist, S., Jurisica, I. and Stagljar, I. (2014) Mammalian Membrane Two-Hybrid assay (MaMTH): a novel split-ubiquitin two-hybrid tool for functional investigation of signaling pathways in human cells, Nature Methods, Mar 23. doi: 10.1038/nmeth.2895. [Epub ahead of print].
  6. ^ Paumi, C.M., Menendez, J., Arnoldo, A., Engels, K., Iyer, K., Thaminy, S., Georgiev, O., Barral, Y., Michaelis, S., and Stagljar, I. (2007) Mapping Protein-Protein Interactions for the Yeast ABC Transporter Ycf1p by Integrated Split-Ubiquitin Membrane Yeast Two-Hybrid (iMYTH) Analysis, Molecular Cell 26, 15-25.
  7. ^ Deribe, Y., Schmidt, M., Chandrashaker, A., Curak, J., Milutinovic, N., Buerke, L., Fetchko, M.J., Schmidt, P., Kittanakom, S., Brown, K., Jurisica, I., Blagoev, B., Zerial, M., Stagljar, I., and Dikic, I. (2009) Regulation of EGF receptor endocytosis by histone deacetylase HDAC6, Science Signaling 2, ra84.
  8. ^ Babu, M., Vlasblom, J., Pu, S., Guo, X., Graham, C., Hnatshak, O., Phanse, S., Bajaj, N., Fong, V., Chandran, S., Punna, T., Bean, B.D.M., Davey, M., Snider, J., Wong, V., Christopolous, C., Zhong, G., Li, J., Vizeacoumar, F., Stagljar, I., Conibear, E., Wodak, S.J., Emili, A., and Greenblatt, J.F. (2012) Interaction Landscape of Membrane Protein Complexes in Saccharomyces cerevisiae, Nature 489, 585-589.
  9. ^ Mak, A.B., Stewart, J.M., Kittanakom, S., Chen, G.I., Curak, J., Gingras, A-C., Mazitschek, R., Neel, B.G., Stagljar, I., and Moffat, J. (2012) Association of CD133, HDAC6 and b-catenin promotes transcription of TCF/LEF target genes and suppresses differentiation in cancer cells, Cell Reports, 2012 Oct 25;2(4):951-63. doi: 10.1016/j.celrep.2012.09.016
  10. ^ Xie, L., Gao, S., Alcaire, S., Wang, Y., Stagljar, I., and Zhen, M. (2013) NLF-1 Regulates Neuronal Excitability through a Conserved Sodium Leak Channel, Neuron 77,1069-1082.
  11. ^ Snider, J., Hanif, A., Lee, M.E., Jin, K., Yu, A.R., Chuk, M., Damjanovic, D., Graham, C., Wierzbicka, M., Tang, P., Balderes, D., Wong, V., San Luis, B-J., Shevelev, I., Sturley, S.L., Boone, C., Babu, M., Zhang, Z., Paumi, C.M., Park, H-O., Michaelis, S., and Stagljar, I. (2013) A global analysis of the Saccharomyces cerevisiae ABC transporter interaction network: towards a greater understanding of membrane transport, Nature Chemical Biology 9, 565-572.

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