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Systematic (IUPAC) name
CAS Number 23434-86-8 YesY
ATC code None
PubChem CID 641115
ChemSpider 556435 N
UNII 5ML58O200F YesY
Chemical data
Formula C15H17NO3
Molar mass 259.300 g/mol
 NYesY (what is this?)  (verify)

Ilepcimide, also known as antiepilepserine, is a piperidine anticonvulsant.[1] It was synthesized by Chinese researchers as an analogue of piperine, the main alkaloid and phytochemical of black pepper (and of other plants in the Piperaceae family), which has been used in the treatment of epilepsy in traditional Chinese medicine and as a nerve tonic in traditional Iranian medicine.[2]

Ilepcimide has serotonergic activity.[1][3][4]


Ilepcimide synthesis:[5]

See also[edit]


  1. ^ a b C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. p. 1116. ISBN 978-0-412-46630-4. Retrieved 30 November 2012. 
  2. ^ Meyer Rosen (23 September 2005). Delivery System Handbook for Personal Care and Cosmetic Products: Technology, Applications and Formulations. William Andrew. p. 159. ISBN 978-0-8155-1682-8. Retrieved 30 November 2012. 
  3. ^ Liu, G.Q., Algeria, S., Ceci, A., Gerattini, S., Gobi, M. and Murai, S. (1984) Stimulation of serotonin synthesis in rat brain after antiepilepserine, an antiepileptic piperine derivative. Biochemical Pharmacology 33:3883-3886
  4. ^ Yan, Q.S., Mishra, P.K., Burger, R.L., Bettendorf, A.F., Jobe, P.C. and Dailey J.W. (1992) Evidence that carbamazepine and antiepilepserine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. J. Pharm & Exp Therap. 261(2):652-659
  5. ^ Xiao, W. J.; Shi, L. L.; Chen, Z. Q.; Huang, Y. Z.; Lang, S. A. (1990). "One-Pot synthesis of (2E)- and (2E, 4E)- unsaturated carboxylic acid amides via organotellurium reagents". Heteroatom Chemistry 1 (3): 245. doi:10.1002/hc.520010309.