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Imidazo[1,2-a]pyridine—an example of imidazopyridine and a core structure of zolpidem and some compounds described below.
Imidazo[1,2-a]pyridine—an example of imidazopyridine and a core structure of zolpidem and some compounds described below.

The imidazopyridines are a class of drugs defined by their chemical structure. In general, they are GABAA receptor agonists, however recently proton pump inhibitors, aromatase inhibitors, NSAIDs and other classes of drugs in this class have been developed as well. Despite usually being similar to them in effect, they are not chemically related to benzodiazepines. As such, GABAA-agonizing imidazopyridines, pyrazolopyrimidines, and cyclopyrrones are sometimes grouped together and referred to as "nonbenzodiazepines." Imidazopyridines include:

Anxiolytics, sedatives and hypnotics (GABAA receptor positive allosteric modulators):


  • Imidazo[1,2-a]pyridines:
    • Mosapramine (brand name クレミン, Cremin)—an atypical antipsychotic used in Japan.[3]

Drugs used for peptic ulcer disease (PUD), GERD and gastroprokinetic agents (motility stimulants):

NSAIDs, analgesics and antimigraine drugs:

Drugs acting on the cardiovascular system:

Drugs for treatment of bone diseases:

Antineoplastic agents:


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