Patients with ongoing symptoms while on PPI therapy are commonly diagnosed with impedance–pH monitoring while continuing their medications. The impedance–pH monitoring diagnostic test determines the frequency of reflux episodes and the time relationship of reflux episodes and symptoms. The impedance–pH monitoring test determines if the patient's symptoms are related to acid reflux, related to nonacid reflux, or not related to reflux of any type. A positive GERD diagnosis is made if acid or nonacid reflux precedes symptoms in a statistically meaningful manner. Patients with a positive impedance–pH monitoring test may benefit from acid-reduction therapy such as fundoplication surgery or endoscopic fundoplication techniques.
- Pritchett JM, Aslam M, Slaughter JC, Ness RM, Garrett CG, Vaezi MF (March 2009). "Efficacy of Esophageal Impedance/pH Monitoring in Patients With Refractory Gastroesophageal Reflux Disease, on and off Therapy". Clin. Gastroenterol. Hepatol. 7 (7): 743–8. doi:10.1016/j.cgh.2009.02.022. PMID 19281866.
- C. j. Hawkey (2012). Textbook of Clinical Gastroenterology and Hepatology (2nd ed.). John Wiley & Sons. p. 186. ISBN 9781405191821.
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