"In God's Hands" is about Furtado's breakup with DJ Jasper Gahunia, the father of her daughter. According to Furtado, the song was, at the time, "as far as I was willing to go in terms of pop right now".
There's also a Spanish version released as "En las manos de Dios", which appears in a Spanish limited edition of Loose.
A music video for the song was shot on 9 May 2007 between 5 and 7 a.m. in Los Angeles, California; it was directed by Jesse Dylan. It features Furtado on a beach during both daytime and nighttime, singing the song while sitting on a tree stump, lying on the sand and holding a white sheet, which she lies under. Furtado is also shown walking on the shore, weeping and looking onto the ocean.
Furtado re-recorded "In God's Hands". "I love country music. Keith Urban's voice is plaintive and sweet; he's a pure songsmith, with an extremely humble tone to his voice. I have always thought that the song "Gods Hands" needed a country singer on it and Keith was my first choice. He's right on the border of country, roots and pop. He really defies description, and those are my favorite kinds of artists."