The layout is similar to the setup used for the Formula OneUnited States Grand Prix between 2000 and 2007, but not identical. It has been reversed to a counterclockwise layout, with a new complex of corners just after the start-finish line, inside Turn 1 of the oval. This means that the bikes do not use any of the banked oval corners. The double-hairpin at the Hulman Straight was replaced with the traditional esses.
The inaugural Red Bull Indianapolis GP took place 99 years after the previous motorcycle race at the track, in 1909.
The first motorsports event at the track consisted of 7 motorcycle races, sanctioned by the Federation of American Motorcyclists (FAM), on August 14, 1909. This was originally planned as a two-day, 15-race program, but ended before the first day was completed, due to concerns over suitability of the track surface for motorcycle use.The Rider with most victories at this grand prix is Nicolas Terol with three victories in the 125cc class, followed by Dani Pedrosa and Marc Márquez with two victories each. and all the others have only one victory.This grand prix has been won only by Spanish, Italian and Australian riders.
^The 2008 250cc race was initially postponed after the MotoGP race due to torrential rain & winds caused by Hurricane Ike just before the start of the race, it was subsequently cancelled for the same reason.