Indy (gene)

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Indy, short for I'm not dead yet, is a gene of a model organism, the fruit fly Drosophila melanogaster. Mutant versions of this gene have doubled the average life span of fruit flies in at least one set of experiments, but this result has been subject to controversy.[1] Its name originates from a well-known comic line in Monty Python and the Holy Grail.[2]

In a Yale University School of Medicine study by lead author and Howard Hughes Medical Institute investigator Gerald I. Shulman, the George R. Cowgill Professor of Physiological Chemistry, Medicine, and Cellular and Molecular Biology, reduced expression of this gene in Drosophila melanogaster flies and C. elegans worms modeled the effects on obesity and diabetes of caloric reduction in primates such as humans.[3]

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  1. ^ Belloir-Furet F (March 1989). "[The role of the ophthalmologist in detecting sexually transmitted diseases caused by Chlamydia trachomatis--apropos of 194 cases]". Bulletin Des Societes d'Ophtalmologie De France. 89 (3): 403–12, 415–6. Bibcode:2009PNAS..106E..54H. doi:10.1073/pnas.0902947106. PMC 2688962.
  2. ^ Clever Drosophila gene names
  3. ^[full citation needed]

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