Inflammatory fibroid polyp

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Inflammatory fibroid polyp
Inflammatory fibroid polyp - low mag.jpg
Micrograph of an inflammatory fibroid polyp. H&E stain.
Classification and external resources

Inflammatory fibroid polyp, abbreviated IFP, is a benign abnormal growth of tissue projecting into the lumen of the gastrointestinal tract.


IFPs consist of spindle cells that are concentrically arranged around blood vessels and have inflammation, especially eosinophils.[1] They may have leiomyoma/schwannoma-like areas with nuclear palisading.

They typically stain with CD34[1] and vimentin,[2] and, generally, do not stain with CD117 and S100.

The endoscopic differential diagnosis includes other benign, pre-malignant and malignant gastrointestinal polyps.

Morphological differential diagnosis[edit]

Additional images[edit]

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  1. ^ a b Daum, O.; Hatlova, J.; Mandys, V.; Grossmann, P.; Mukensnabl, P.; Benes, Z.; Michal, M. (May 2010). "Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors).". Virchows Arch. 456 (5): 491–7. doi:10.1007/s00428-010-0914-8. PMID 20393746. 
  2. ^ Kolodziejczyk, P.; Yao, T.; Tsuneyoshi, M. (Nov 1993). "Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases.". Am J Surg Pathol. 17 (11): 1159–68. doi:10.1097/00000478-199311000-00009. PMID 8214261.