Inflammatory myofibroblastic tumour

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Inflammatory myofibroblastic tumour
Other namesInflammatory fibrosarcoma[1]
Inflammatory myofibroblastic tumour - high mag.jpg
Micrograph of an inflammatory myofibroblastic tumour of the kidney. Kidney biopsy. H&E stain.

Inflammatory myofibroblastic tumour is a lesional pattern of inflammatory pseudotumour, as plasma cell granuloma.[2] It is abbreviated IMT.


The symptoms depend on the specific location of the tumour, which can be anywhere in the body.[3]


Inflammatory myofibroblastic tumours are characterized by a mix of inflammatory cells, e.g. plasma cells, lymphocytes and eosinophils, and bland spindle cells without nuclear atypia. These tumours may have necrosis, hemorrhage, focal calcification and mitotic activity.

The histologic differential diagnosis includes:

Approximately half of IMTs have a rearrangement of the ALK gene.[4]


Inflammatory myofibroblastic tumours are diagnosed based on their appearance under the microscope, by pathologists.[5] Medical imaging findings are non-specific.



Main modality for treatment is surgical only.

See also[edit]


  1. ^ "Inflammatory myofibroblastic tumor | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". Retrieved 28 June 2019.
  2. ^ Manohar, B.; Bhuvaneshwari, S. (Jan 2011). "Plasma cell granuloma of gingiva". J Indian Soc Periodontol. 15 (1): 64–6. doi:10.4103/0972-124X.82275. PMC 3134051. PMID 21772725.
  3. ^ Singhal, M.; Ramanathan, S.; Das, A.; Singh, G.; Bagga, R.; Khandelwal, N. (2011). "Omental inflammatory myofibroblastic tumour mimicking peritoneal carcinomatosis". Cancer Imaging. 11: 19–22. doi:10.1102/1470-7330.2011.0005 (inactive 2019-08-20). PMC 3080123. PMID 21435987.
  4. ^ Gleason, BC.; Hornick, JL. (Apr 2008). "Inflammatory myofibroblastic tumours: where are we now?". J Clin Pathol. 61 (4): 428–37. doi:10.1136/jcp.2007.049387. PMID 17938159.
  5. ^ Soga, H.; Yao, A.; Matsushita, K.; Shimogaki, H.; Kawabata, G. (2011). "Inflammatory pseudotumor of the retroperitoneum removed via a retroperitoneoscopic approach". JSLS. 15 (2): 272–4. doi:10.4293/108680811X13071180406871. PMC 3148889. PMID 21902993.
  6. ^ Kaitoukov, Y; Rakovich, G; Trahan, S; Grégoire, J (2011). "Inflammatory pseudotumour of the lung". Canadian Respiratory Journal. 18 (6): 315–7. doi:10.1155/2011/702646. PMC 3267618. PMID 22187684.
  7. ^ Sanchez, P. G.; Madke, G. R.; Pilla, E. S.; Foergnes, R; Felicetti, J. C.; Valle, Ed; Geyer, G (2007). "Endobronchial inflammatory pseudotumor: A case report". Jornal Brasileiro de Pneumologia : Publicacao Oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 33 (4): 484–6. doi:10.1590/S1806-37132007000400020. PMID 17982543.
  8. ^ Sari, A; Tunakan, M; Ünsal, B; Ekıncı, N; Rezanko, T; Elçın, F; Aydoğdu, Z (2010). "Inflammatory pseudotumor of the liver diagnosed by needle biopsy: Report of three cases (one with neuroendocrine tumor of the rectum and lung)". The Turkish Journal of Gastroenterology. 21 (3): 308–12. doi:10.4318/tjg.2010.0107. PMID 20931439.
  9. ^ Yaghi MD. A case report of inflammatory myofibroblastic tumor of urinary bladder. Urol Ann [serial online] 2016 [cited 2016 Jul 18];8:366-8. Available from:
  10. ^ Dhua, Anjan Kumar; Garg, Mohit; Sen, Amita; Chauhan, Devender S. (May 2013). "Inflammatory myofibroblastic tumor of parotid in infancy—A new entity". International Journal of Pediatric Otorhinolaryngology. 77 (5): 866–868. doi:10.1016/j.ijporl.2013.02.020. PMID 23562234.

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