Inhibitor of apoptosis domain

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Inhibitor of Apoptosis domain
1QBH BIRC2.png
NMR solution structure of the BIR domain of human BIRC2 protein.[1] The protein is rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) while the coordinated zinc is represented by a grey sphere.

The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation.[2] Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6.[2][3]

BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion.[4] They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.

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  1. ^ PDB: 1QBH​;Hinds MG, Norton RS, Vaux DL, Day CL (July 1999). "Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat". Nat. Struct. Biol. 6 (7): 648–51. doi:10.1038/10701. PMID 10404221.
  2. ^ a b Silke J, Vaux DL (May 2001). "Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis". J. Cell Sci. 114 (Pt 10): 1821–7. PMID 11329368.
  3. ^ Verhagen AM, Coulson EJ, Vaux DL (2001). "Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs". Genome Biol. 2 (7): REVIEWS3009. doi:10.1186/gb-2001-2-7-reviews3009. PMC 139420. PMID 11516343.
  4. ^ Birnbaum MJ, Clem RJ, Miller LK (April 1994). "An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs". J. Virol. 68 (4): 2521–8. PMC 236730. PMID 8139034.
This article incorporates text from the public domain Pfam and InterPro: IPR001370