Inner Sanctum may refer to:
- Inner Sanctum (1948 film), an American film directed by Lew Landers
- Inner Sanctum (1991 film), a film starring Tanya Roberts
- Inner Sanctum (TV series), an American television series from 1954
- Inner Sanctum Mystery, a 1941-1952 American radio program, and related film and television productions
- Inner Sanctum Records, a defunct record shop in Austin, Texas, United States
- The Inner Sanctum, a 2007 album by Saxon
- Inner Sanctum (album), a 2019 live album and video by Pet Shop Boys
- "Inner Sanctum", a song by Behemoth from the 2007 album The Apostasy
- Inner Sanctum (band), a Bangalore metal band
- "Inner Sanctum", a track and limited edition single released from the 2016 Pet Shop Boys album Super
- Might and Magic Book One: The Secret of the Inner Sanctum, the first game of Might and Magic series.
- Sanctum sanctorum, a Latin phrase meaning "Holy of Holies"