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An inorganic compound is a chemical compound that is not an organic compound. There is no clear or universally agreed-upon distinction between organic and inorganic compounds, but common definitions focus on the presence or absence of carbon (or certain kinds of carbon bonds) or the source from which the compound is derived. Inorganic compounds are traditionally viewed as being synthesized by the agency of geological systems. In contrast, organic compounds are found in biological systems. Organic chemists traditionally refer to any molecule containing carbon as an organic compound and by default this means that inorganic chemistry deals with molecules lacking carbon. As many minerals are of biological origin, biologists may distinguish organic from inorganic compounds in a different way that does not hinge on the presence of a carbon atom. Pools of organic matter, for example, that have been metabolically incorporated into living tissues persist in decomposing tissues, but as molecules become oxidized into the open environment, such as atmospheric CO2, this creates a separate pool of inorganic compounds. The International Union of Pure and Applied Chemistry, an agency widely recognized for defining chemical terms, does not offer definitions of inorganic or organic compounds. Hence, the definition for an inorganic versus an organic compound in a multidisciplinary context spans the division between organic life living (or animate) and inorganic non-living (or inanimate) matter.
The Wöhler synthesis is the conversion of ammonium cyanate into urea. This chemical reaction was discovered in 1828 by Friedrich Wöhler and is considered the starting point of modern organic chemistry.
The Wöhler synthesis is of great historical significance because for the first time an organic compound was produced from inorganic reactants. This finding went against the mainstream theory of that time called vitalism, which stated that organic matter possessed a special force or vital force inherent to all things living. For this reason a sharp boundary existed between organic and inorganic compounds. Urea was discovered in 1799 and could until 1828 only be obtained from biological sources such as urine. Wöhler reported to his mentor Berzelius:
"I cannot, so to say, hold my chemical water and must tell you that I can make urea without thereby needing to have kidneys, or anyhow, an animal, be it human or dog".
Inorganic compounds can be defined as any compound that is not organic compound. Some simple compounds which contain carbon are usually considered inorganic. These include carbon monoxide, carbon dioxide, carbonates, cyanides, cyanates, carbides, and thiocyanates. In contrast, methane and formic acid are generally considered to be simple examples of organic compounds, although the Inorganic Crystal Structure Database (ICSD), in its definition of "inorganic" carbon compounds, states that such compounds may contain either C-H or C-C bonds, but not both.
A large class of compounds discussed in inorganic chemistry textbooks are coordination compounds. Examples range from substances that are strictly inorganic, such as [Co(NH3)6]Cl3, to organometallic compounds, such as Fe(C5H5)2, and extending to bioinorganic compounds, such as the hydrogenase enzymes.
Minerals are mainly oxides and sulfides, which are strictly inorganic, although they may be of biological origin. In fact, most of the Earth is inorganic. Although the components of Earth's crust are well-elucidated, the processes of mineralization and the composition of the deep mantle remain active areas of investigation, which are covered mainly in geology-oriented venues.
- Major textbooks on inorganic chemistry, however, decline to define inorganic compounds: Holleman, A. F.; Wiberg, E. "Inorganic Chemistry" Academic Press: San Francisco, 2001. ISBN 0-12-352651-5; Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. ISBN 0-08-037941-9., Cotton, F. Albert; Wilkinson, Geoffrey (1988), Advanced Inorganic Chemistry (5th ed.), New York: Wiley-Interscience, ISBN 0-471-84997-9
- ., Arnoldischen Buchhandlung, Dresden and Leipzig, 1827. ISBN 1-148-99953-1. Brief English commentary in English can be found in Bent Soren Jorgensen "More on Berzelius and the vital force" J. Chem. Educ., 1965, vol. 42, p 394. doi:10.1021/ed042p394
- "organic compound – chemical compound". Encyclopedia Britannica.
- "ICSD". fiz-karlsruhe.de.
- Newman, D. K.; Banfield, J. F. (2002). "Geomicrobiology: How Molecular-Scale Interactions Underpin Biogeochemical Systems". Science. 296 (5570): 1071–1077. doi:10.1126/science.1010716. PMID 12004119.
- Dan Berger, Bluffton College, analysis of varying inappropriate definitions of the inorganic-organic distinction: Otherwise consistent linked material differing from current article in downplaying the carbon present vs carbon absent distinctive: